Highlights The success rate of the lower leg salvage is high, reach the percentage of 91.8% (90/98).External fixation is less invasive, with achieving adequate stability to repair the arterial injury timely, can lower the King Sleigh Storage Bed ischemic time, and beneficial for the following bone or soft tissue repair.Treating the Tumblers patient
A Mean-VaR Based Deep Reinforcement Learning Framework for Practical Algorithmic Trading
It is difficult to automatically produce trading signals based on previous transaction data and the financial status of assets because of the significant noise and unpredictability of capital markets.This paper proposes an innovative algorithm to solve the optimal portfolio problem in stock market trading activities.Our novel portfolio trading stra
Opioids exacerbate inflammation in people with well-controlled HIV
IntroductionPeople with HIV (PWH) are known to have underlying inflammation and immune activation despite virologic control.Substance use including opioid dependence is common in this population and is associated with increased morbidity and reduced lifespan.The primary objective of the present study termed opioid immunity study (OPIS), was to inve
CAR-T cell therapy for juvenile-onset autoimmune diseases: a promising future?
Abstract Chimeric antigen receptor (CAR) T-cell therapy targeting B cells has shown promising results, including drug-free remission, in adult-onset autoimmune diseases.Extending this Custom Wooden Parterre therapeutic approach to the pediatric population, particularly for juvenile autoimmune diseases, presents an exciting opportunity.However, chal
The effects of sociodemographic factors on quality of life among people aged 50 years or older are not unequivocal: comparing SF-12, WHOQOL-BREF, and WHOQOL-OLD
Robbert JJ Gobbens,1–3 Roy Remmen3 1Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Amsterdam, the Netherlands; 2Zonnehuisgroep Amstelland, Amstelveen, the Netherlands; 3Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium Object